CAMBRIDGE, United Kingdom and NEW YORK, August 12, 2025 – Artios Pharmaceuticals Limited (“Artios”), a biopharmaceutical company committed to realizing the therapeutic power of targeting the DNA damage response (“DDR”) in cancer, today announced the appointment of Mike Andriole as Chief Executive Officer (CEO) and Director. He joins the company with a biopharmaceutical career that spans nearly 25 years, marked by a consistent theme of focused execution across clinical, corporate, and strategic development. His appointment supports the company’s transition into a late-stage clinical organization preparing for the potential commercialization of alnodesertib (formerly ART0380) in ATM-deficient solid tumors. Mike Andriole succeeds Niall Martin, Artios’ founding CEO, who will remain an advisor to the company through a transition period.

“On behalf of the Board, I’m thrilled to welcome Mike Andriole to Artios. As the company advances its lead program into later stages of clinical development, Mike’s extensive late-stage oncology experience and strategic focus make him a perfect fit to lead Artios,” said Samantha Truex, newly appointed Board Chair. “I’d like to thank Niall for his outstanding leadership and dedication. He has built Artios based on fundamental scientific leadership in the DDR space and has been instrumental in guiding Artios from its discovery platform roots to having two DNA damage response-based therapeutic candidates in the clinic.”

“Artios is entering its next chapter with tremendous momentum as a leader in the DDR field capable of redefining standards of care in the treatment of certain solid tumors,” said Mike Andriole, Chief Executive Officer of Artios. “I’m excited to lead the company at this pivotal stage and build on its strong scientific foundation as we take alnodesertib into late-stage development and prepare for potential commercialization. I look forward to collaborating with the talented Artios team to deliver on our mission to bring life-changing first-in-class therapies to patients  worldwide who have few treatment options.”

Mike Andriole joins Artios after having most recently served as President, CEO and Director of Chimerix, Inc., where he led the company’s acquisition and development of dordaviprone (Modeyso®), a first-in-class small molecule imipridone approved on August 6, 2025, as the first treatment for recurrent H3 K27M-mutant diffuse midline glioma, a type of malignant brain tumor in children and young adults. Chimerix was acquired in April 2025 by Jazz Pharmaceuticals in a $935 million all-cash transaction. Previously, he was Chief Financial Officer and head of corporate development at Endocyte, Inc., where he led a series of strategic transactions that culminated in a $2.1 billion all-cash acquisition by Novartis driven by the late-phase development of its first-in-class targeted radioligand therapy, Lu¹⁷⁷-PSMA-617, which later became the first product approved specifically for PSMA-positive metastatic castration resistant prostate cancer (Pluvicto®). Earlier in his career, Mike spent 16 years at Eli Lilly and Company in various financial, marketing, and global business development roles.

About Alnodesertib (ART0380)

Alnodesertib, formerly known as ART0380, is a first-in-class, orally administered, selective small molecule inhibitor of ataxia-telangiectasia and Rad3-related protein (ATR). Artios’ differentiated approach combines alnodesertib with a low dose of the chemotherapy irinotecan, targeting cancers with high endogenous replication stress, such as those with ATM protein deficiency. Data presented at the AACR Annual Meeting 2025 from the ongoing STELLA Phase 1/2a clinical trial demonstrated a 50% confirmed overall response rate (cORR) in patients with ATM-negative solid tumors at the recommended Phase 2 dose (RP2D), along with a favorable safety profile. In addition, the data highlighted two confirmed complete responses in patients with heavily pretreated pancreatic cancer as well as partial responses in patients with pancreatic cancer, colorectal cancer, and six other ATM deficient tumor types.

About Artios Pharmaceuticals Ltd.

Artios is pioneering approaches in the DNA damage response (DDR) field through its comprehensive anti-cancer approach and the deep experience of its team of DDR drug developers. The company’s clinical-stage candidates, ATR inhibitor alnodesertib and DNA Polymerase theta (Polθ) inhibitor ART6043, as well as its pre-clinical programs, including DDRi-ADCs, are designed with differentiated pharmaceutical properties and novel biological approaches to precisely eliminate a cancer cell’s remaining survival mechanisms. Artios’ mission is to develop new classes of medicines that exploit DDR pathways with the aim of improving outcomes for patients with hard-to-treat cancers.

Visit our website at www.artios.com to learn more about the company.

Media Inquiries

Trophic Communications

Jacob Verghese or Verena Schossmann

Tel: +49 151 7441 6179

Email: artios@trophic.eu

¹ Artios received approval of “alnodesertib” as the International Nonproprietary Name (INN) for ART0380 by the World Health Organization (WHO)

² ATM protein levels determined by immunohistochemistry and depicted on an H-score scale: ATM negative = 0; ATM low = 1-50; H-score scale goes from 0 to 300

CAMBRIDGE, United Kingdom and NEW YORK, April 29, 2025 – Artios Pharmaceuticals Limited (“Artios”), a clinical-stage biotech company led by pioneers of DNA damage response (“DDR”) drug development, today reported encouraging data from its ongoing STELLA Phase 1/2a trial (NCT04657068) in an oral presentation at the American Association for Cancer Research (AACR) Annual Meeting 2025 in Chicago. The presentation by Principal Investigator Susanna Ulahannan, MD, Associate Professor, Stephenson Cancer Center at the University of Oklahoma and Director, Drug Development, Sarah Cannon Research Institute (SCRI) at OU Health Stephenson Cancer Center, highlighted the Phase 1/2a clinical data from the STELLA trial of Artios’ lead candidate, ART0380, in combination with low-dose irinotecan in advanced or metastatic solid tumors.

Artios is pursuing a differentiated clinical development path with its lead product candidate, ART0380, which selectively targets a protein kinase called Ataxia telangiectasia and Rad3-related (ATR). ATR plays a key role in the cellular response to replication stress, a process that can occur endogenously or exogenously, for example via chemotherapy. Many cancers exhibit high endogenous replication stress, such as Ataxia-Telangiectasia Mutated (ATM) protein deficiency found in up to 24% of high-unmet need solid tumors. Artios’ innovative approach exploits replication stress to kill cancer cells through triple targeting: selecting cancers with high replication stress, inducing further replication stress with a low dose of irinotecan, and preventing cellular rescue by inhibiting ATR with ART0380.

“Artios is exploiting a new area of DNA damage response called replication stress with ART0380, and the data from our Phase 1/2a study shows robust clinical activity and good tolerability in a large, identifiable patient population,” said Ian Smith, Chief Medical Officer of Artios. “These are unprecedented data for the ATR inhibitor class, and they validate our unique approach of combining ART0380 with a low dose of irinotecan to amplify replication stress. We are encouraged by the incidence and durability of the responses in ATM-deficient cancers, including those of particularly high unmet need, such as pancreatic and colorectal cancer.”

Summary of Key Clinical Results:

Artios completed patient enrollment in the dose escalation and initial expansion. As of the data cut-off in February 2025, 87 patients with advanced/metastatic solid tumors who had no satisfactory alternative therapy available to them were treated with ART0380 in combination with low-dose irinotecan, of which 58 patients were treated at the RP2D (recommended Phase 2 dose). These patients’ tumors had varying levels of ATM protein.

• The combination treatment at the RP2D showed a meaningful duration of response and prolonged clinical benefit across multiple histologies
  • 37% confirmed overall response rate (cORR) in patients with ATM-negative¹ and ATM-low¹ cancers (14/38), according to RECIST
    • 50% cORR in ATM-negative cancers (10/20) with a median duration of response (mDoR) of 5.7 months (several responses ongoing)
    • 22% cORR in ATM-low cancers (4/18) with the median duration of response not reached
  • Responses were observed in 8 different solid tumor types
• The combination had a favorable safety profile, was well tolerated, and was shown to be suitable for long-term dosing

The 21-day combination treatment regimen at the RP2D includes administering ART0380 (200mg) on days 1 – 3 and 8 – 10, and irinotecan (60mg/m²) on days 1 and 8.

“The first results from the ongoing STELLA clinical trial are compelling and demonstrate the potential for ART0380-irinotecan combination treatment in ATM biomarker-driven tumors. I am encouraged by the clinical activity and durable responses across multiple cancer indications in heavily pretreated patients, especially considering the complete responses observed in metastatic pancreatic cancer,” added Susanna Ulahannan, MD, Director, Drug Development, SCRI at OU Health Stephenson Cancer Center, USA.

The Phase 1/2a trial for ART0380 is conducted with SCRI’s contract research organization, SCRI Development Innovations. Based on the meaningful clinical responses observed, Artios is initiating expansion studies in earlier-line settings, including colorectal and pancreatic cancers, to enable pivotal development of ART0380.

About ART0380

ART0380 is an orally administered, selective small molecule inhibitor of ataxia telangiectasia and Rad3-related protein (ATR) with first- and best-in-class potential. ATR is activated as the cell’s response to replication stress frequently occurring in rapidly multiplying cells. Inhibiting ATR with ART0380 removes a cancer cell’s ability to repair damaged DNA, leading to the killing of cancerous cells. ART0380 is designed to maximize the therapeutic window and is optimized for combination with DNA damaging therapy to improve patient outcomes. It is currently being evaluated in multiple clinical settings to identify its potential in high replication stress tumors. ART0380 was originally in-licensed by Artios from The University of Texas MD Anderson Cancer Center and ShangPharma Innovation in 2019.  The molecule was discovered as part of a collaboration between ShangPharma and MD Anderson’s Therapeutics Discovery Division.

About Artios Pharmaceuticals Ltd.

Artios is pioneering approaches in the DNA damage response (DDR) field through its comprehensive anti-cancer approach and the deep experience of its team of DDR drug developers. The company’s clinical-stage candidates, ATR inhibitor ART0380 and DNA Polymerase theta (Polθ) inhibitor ART6043 are designed with differentiated pharmaceutical properties and novel biological approaches to precisely eliminate a cancer cell’s remaining survival mechanisms. Artios’ mission is to develop new classes of medicines that exploit DDR pathways with the aim of improving outcomes for patients with hard-to-treat cancers.

Visit our website at www.artios.com to learn more about the company.

Media Inquiries

Trophic Communications

Jacob Verghese or Verena Schossmann

Tel: +49 151 7441 6179

Email: artios@trophic.eu

¹ ATM protein levels determined by immunohistochemistry and depicted on an H score scale: ATM negative = 0; ATM low = 1-50; H-score scale goes from 0 to 300

Details of the oral presentation:

Abstract Title: First results of ART0380 (an ATR kinase inhibitor) with low dose irinotecan in advanced or metastatic tumors

Presenter: Susanna Ulahannan, MD, Associate Professor, Stephenson Cancer Center at the University of Oklahoma/SCRI, OK, USA

Date: Tuesday, April 29, 2025

Time: 3:50 pm – 4:00 pm CDT

Location: Room S406 (Vista Ballroom) – McCormick Place South (Level 4)

Details of the poster presentation on ART0380:

Abstract Title: Combination of the ATR inhibitor, ART0380, with irinotecan for treating ATM-negative tumors

Presenter: Helen M. R. Robinson, VP of Biology, Artios

Session: PO.ET06.02 – DNA Damage Response and Modulation of DNA Repair 1

Date Monday, April 28, 2025

Time: 2:00 pm – 5:00 pm CDT

Location: Section 16

The full poster abstract is available on the AACR Annual Meeting website.

Details of the poster presentation on ART6043:

Abstract Title: DNA polymerase theta inhibitor, ART6043, potentiates the efficacy of 177Lu- and 225Ac-based radioligand therapies in vitro and in vivo

Presenter: Marco Ranzani, Associate Director, Artios

Session: PO.ET06.02 – DNA Damage Response and Modulation of DNA Repair 1

Date Monday, April 28, 2025

Time: 2:00 pm – 5:00 pm CDT

Location: Section 16

The full poster abstract is available on the AACR Annual Meeting website.

About Artios Pharmaceuticals Ltd.

Artios leads the DNA damage response field through its comprehensive anti-cancer approach and the deep experience of its team of pioneering DDR drug developers. The company’s clinical-stage candidates, ATR inhibitor ART0380 and DNA Polymerase theta (Polθ) inhibitor ART6043, are designed with differentiated pharmaceutical properties and novel biological approaches to precisely eliminate a cancer cell’s remaining survival mechanisms. Artios’ mission is to develop new classes of DDR drugs that achieve an unreached level of therapeutic impact for patients with hard-to-treat solid tumors.

Visit our website at www.artios.com to learn more about the company.

For more information, please contact:

Media and Investor Relations Inquiries

Trophic Communications

Jacob Verghese or Verena Schossmann

Tel: +49 151 7441 6179

Email: artios@trophic.eu

Artios Pharmaceuticals to Present at the 43rd Annual J.P. Morgan

Niall Martin, PhD, Artios’ Chief Executive Officer, will present the company’s strategic vision for 2025 and beyond on January 16 at 08:00 am PST (11:00 am EST / 04:00 pm UTC) in the Elizabethan C room at The Westin St. Francis, 335 Powell Street, San Francisco.

About Artios Pharmaceuticals Ltd.

Artios leads the DNA damage response field through its comprehensive anti-cancer approach and the deep experience of its team of pioneering DDR drug developers. The company’s clinical-stage candidates, ATR inhibitor ART0380 and Polymerase theta (Polθ) inhibitor ART6043 are designed with differentiated pharmaceutical properties and novel biological approaches to precisely eliminate a cancer cell’s remaining survival mechanisms. Artios’ mission is to develop new classes of DDR drugs that achieve an unreached level of therapeutic impact for patients with hard-to-treat solid tumors.

Visit our website at www.artios.com to learn more about the company.

For more information, please contact:

Artios Pharmaceuticals Ltd.

Niall Martin, CEO

Email: info@artiosuk.com

Media Inquiries

Trophic Communications

Jacob Verghese or Verena Schossmann

Tel: +49 151 7441 6179

Email: artios@trophic.eu

Niall Martin, Chief Executive Officer of Artios, said: “We are delighted to welcome Chris, a prominent research analyst to our Board of Directors. His deep knowledge of the oncology therapeutic landscape and breadth of relationships within the investment community will be invaluable as we further advance our robust DDR pipeline.”

In February 2024, RTW Biotech Opportunities Ltd, a New York-based investment firm focused on the life sciences sector entered into an agreement to acquire London-based biotechnology venture capital firm Arix Bioscience PLC. Through the acquisition, RTW acquired Arix’s portfolio, of which Artios was a large equity position.

Chris Liu, Ph.D. Board Director of Artios, added: “RTW is now a top shareholder of Artios following the acquisition of Arix and the expansion of our equity interest, which reflects both our confidence and excitement in Artios’ innovative platform targeting broad aspects of the DNA damage response. I look forward to partnering with the team and the Board to support them in their mission to bring new therapies to patients suffering from difficult to treat solid tumors.”

Chris Liu, Ph.D. brings over 10 years of financial and biotechnology experience, specializing in oncology therapeutics across diverse indications, technology platforms and stages of development. He currently serves as a Senior Research Analyst at RTW where he leads oncology research on biotechnology companies and covers life sciences companies in China. Prior to joining RTW, Chris spent 5 years in Business Development at GenScript, where his work focused on antibody drug discovery and development including novel immuno-oncology targets. He also helped design and optimize chimeric antigen receptor (CAR) constructs for CAR-T cell therapy companies such as Kite, Juno, and Bellicum. Chris received a Ph.D. in Biochemistry from SUNY Stony Brook and a B.S. in Chemistry from Fudan University. He also received his Master of Business Administration (MBA) in Finance and Management from NYU Stern School of Business. He currently serves on the board of NiKang Therapeutics, Oricell Therapeutics and Nuance Pharma as a Board Director or Observer.

About Artios
Artios is on a mission to kill cancer by exploiting DNA damage response (DDR) and repair pathways that are leveraged by cancer cells to promote their survival. Our specialized DcoDeR platform integrates Artios’ leadership capabilities, expertise and experience in DNA damage biology and drug discovery to systematically discover and develop medicines targeting the totality of the DDR. We have built an extensive DDR focused pipeline designed to address areas of high unmet needs across solid tumour indications including our ATR inhibitor, ART0380, and our Polθ inhibitor, ART6043, as monotherapies and with combination treatments. Together with our strategic partnerships with Merck KGaA and Novartis, and research collaborations with premiere institutions like Cancer Research UK, The Institute of Cancer Research, The Netherlands Cancer Institute, and the Crick Institute we are pioneering validated approaches to DDR drug discovery. Visit our website at https://www.artios.com/ for more information about the company and our pipeline.

Niall Martin, Chief Executive Officer of Artios, said: “Christine is a seasoned CFO with robust capital markets expertise and a deep understanding of the industry landscape. We are pleased to welcome her to the Artios executive team where she will play a key leadership role in the U.S. and further strengthen our global presence. Importantly, her track record of raising capital, preparing companies for IPO, and experience with partnerships and M&A will position us for success as we continue to advance our leading DDR pipeline.”

Before joining Artios, Christine most recently held executive leadership roles at Excision Biotherapeutics, Inc. and Emendo Biotherapeutics, where she successfully led financial strategy and corporate partnering, improved operational efficiency, and facilitated substantial growth. She will join the Company’s U.S. subsidiary in the New York office.

Christine Silverstein, Chief Financial Officer of Artios, added: “As recognized innovators in DDR drug discovery, Artios’ advanced pipeline targeting the DNA damage response offers cutting-edge approaches for difficult-to-treat cancers. I am excited to join Artios at this pivotal time, with clinical data expected for lead programs including ATR inhibitor ART0380 and novel Pol theta inhibitor ART6043 over the next 12 months. I look forward to partnering with the Artios team as we approach this next stage of growth and work to advance potentially life-extending therapies for the treatment of a broad range of solid tumors.”

Christine Silverstein has over 15 years of financial leadership experience spanning strategic and operational roles across both private and public biopharmaceutical companies. Prior to joining Artios, she most recently served as CFO of Excision Biotherapeutics, Inc., where she established numerous corporate functions and led financial planning, strategy, and initial public offering (IPO) readiness activities. Formerly as CFO of Emendo Biotherapeutics (acquired in December 2020 by AnGes, Inc.), Silverstein established the Company’s U.S. operations and capital market footprint for IPO preparedness as well as completed the M&A transaction. During her time at Abeona Therapeutics, Silverstein operated in multiple senior executive roles including CFO and Principal Financial Officer. Earlier in her career, she drove internal capital markets strategy at Relmada Therapeutics, Inc., and held senior executive roles within biotechnology venture fund SCO Capital Partners. Silverstein began her career in the financial services industry where she was instrumental in advising clients on transaction considerations and formulating effective U.S. public listing and financing strategies. Silverstein currently serves on the board of directors at Marinus Pharmaceuticals and Abeona Therapeutics Inc. Silverstein holds a B.S. from the Peter Tobin College of Business at St. John’s University and has earned various accreditations from the Financial Industry Regulatory Authority (FINRA) and Harvard University.

About Artios
Artios is on a mission to kill cancer by exploiting DNA damage response (DDR) and repair pathways that are leveraged by cancer cells to promote their survival. Our specialized DcoDeR platform integrates Artios’ leadership capabilities, expertise and experience in DNA damage biology and drug discovery to systematically discover and develop medicines targeting the totality of the DDR. We have built an extensive DDR focused pipeline designed to address areas of high unmet needs across solid tumour indications including our ATR inhibitor, ART0380, and our Polθ inhibitors, ART4215 and ART6043, as monotherapies and with combination treatments. Together with our strategic partnerships with Merck KGaA and Novartis, and research collaborations with premiere institutions like Cancer Research UK, The Institute of Cancer Research, The Netherlands Cancer Institute, and the Crick Institute we are pioneering validated approaches to DDR drug discovery. Visit our website at https://www.artios.com/ for more information about the company and our pipeline.

For more information about Artios Pharmaceuticals Ltd., please contact:

Investor Relations Contact:
LifeSci Advisors
Alexandra Folias
E: afolias@lifesciadvisors.com